Benzyl Bromide → HCID 19047278, compound

Participants

Reaction Steps

A 300 mg portion of 2-(4-methyl-1-piperazinyl)-benzoxazole was dissolved in 5 ml of THF. Under cooling with ice, 354 mg of benzyl bromide was added to the thus prepared solution, and the reaction was carried out for 1 hour at the same temperature and then for 22 hours at room temperature. The thus formed precipitate was collected by filtration and washed with acetone. The filtrate was concentrated under a reduced pressure, and the resulting residue was dissolved in 50 ml of water, washed with ethyl acetate and then lyophilized to obtain 496 mg of the title compound.

Provenance & Evidence