Benzyl Bromide → HCID 19047278, compound

HRID 1780659Notes

Reaction equation

HRID 1780659 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8]2[O:9][C:10]3[CH:16]=[CH:15][CH:14]=[CH:13][C:11]=3[N:12]=2)[CH2:4][CH2:3]1.[CH2:17]([Br:24])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>C1COCC1>[Br-:24].[CH2:17]([N+:2]1([CH3:1])[CH2:3][CH2:4][N:5]([C:8]2[O:9][C:10]3[CH:16]=[CH:15][CH:14]=[CH:13][C:11]=3[N:12]=2)[CH2:6][CH2:7]1)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

Participants

4

Reactant 2

HCID 7498Benzyl BromideHCID 37945392-(4-methylpiperazino)-1,3-benzoxazole

Product 1

HCID 19047278HCID 19047278, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A 300 mg portion of 2-(4-methyl-1-piperazinyl)-benzoxazole was dissolved in 5 ml of THF. Under cooling with ice, 354 mg of benzyl bromide was added to the thus prepared solution, and the reaction was carried out for 1 hour at the same temperature and then for 22 hours at room temperature. The thus formed precipitate was collected by filtration and washed with acetone. The filtrate was concentrated under a reduced pressure, and the resulting residue was dissolved in 50 ml of water, washed with ethyl acetate and then lyophilized to obtain 496 mg of the title compound.

Workup

  1. additionwas added to the thus prepared solution
  2. waitfor 22 hours at room temperature
  3. filtrationThe thus formed precipitate was collected by filtration
  4. washwashed with acetone
  5. concentrationThe filtrate was concentrated under a reduced pressure
  6. dissolutionthe resulting residue was dissolved in 50 ml of water
  7. washwashed with ethyl acetate

Sources & evidence

ORD record
ord-c6fcee7b05484d2bb3c0a21c12197e61
Source dataset
uspto-grants-1997_05
Patent number
US05631257

Reaction notes

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