Dimethylformamide → HCID 19047289, compound

HRID 1780660Notes

Reaction equation

HRID 1780660 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8]2[O:9][C:10]3[CH:16]=[CH:15][CH:14]=[CH:13][C:11]=3[N:12]=2)[CH2:4][CH2:3]1.[Br:17]C[C:19]#[N:20].[CH3:21]N(C=O)C>>[Br-:17].[C:19]([CH2:1][N+:2]1([CH3:21])[CH2:3][CH2:4][N:5]([C:8]2[O:9][C:10]3[CH:16]=[CH:15][CH:14]=[CH:13][C:11]=3[N:12]=2)[CH2:6][CH2:7]1)#[N:20]

Participants

4

Reactant 3

HCID 6228DimethylformamideHCID 11534BromoacetonitrileHCID 37945392-(4-methylpiperazino)-1,3-benzoxazole

Product 1

HCID 19047289HCID 19047289, compound

Procedure

A 150 mg portion of 2-(4-methyl-1-piperazinyl)-benzoxazole was dissolved in 3 ml of DMF. Under cooling with ice, 0.052 ml of bromoacetonitrile was added to the thus prepared solution, and the reaction was carried out for 1 hour at the same temperature and then for 24 hours at room temperature. The reaction solution was concentrated under a reduced pressure, and 5 ml of acetone was added to the resulting residue. The precipitate thus formed was collected by filtration, washed with acetone and then dried to obtain 228 mg of the title compound.

Workup

  1. additionwas added to the thus prepared solution
  2. waitfor 24 hours at room temperature
  3. concentrationThe reaction solution was concentrated under a reduced pressure, and 5 ml of acetone
  4. additionwas added to the resulting residue
  5. customThe precipitate thus formed
  6. filtrationwas collected by filtration
  7. washwashed with acetone
  8. customdried

Sources & evidence

ORD record
ord-fed4fe75d8de42df88e4d7d1c658bf2a
Source dataset
uspto-grants-1997_05
Patent number
US05631257

Reaction notes

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