1-Acetoxy-2-bromoethane → HCID 19047280, compound

HRID 1780661Notes

Reaction equation

HRID 1780661 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8]2[O:9][C:10]3[CH:16]=[CH:15][CH:14]=[CH:13][C:11]=3[N:12]=2)[CH2:4][CH2:3]1.[C:17]([O:20][CH2:21][CH2:22][Br:23])(=[O:19])[CH3:18]>CN(C=O)C>[Br-:23].[CH2:21]([O:20][C:17]([CH2:18][N+:2]1([CH3:1])[CH2:3][CH2:4][N:5]([C:8]2[O:9][C:10]3[CH:16]=[CH:15][CH:14]=[CH:13][C:11]=3[N:12]=2)[CH2:6][CH2:7]1)=[O:19])[CH3:22]

Participants

4

Reactant 2

HCID 135641-Acetoxy-2-bromoethaneHCID 37945392-(4-methylpiperazino)-1,3-benzoxazole

Product 1

HCID 19047280HCID 19047280, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A 110 mg portion of 2-(4-methyl-1-piperazinyl)-benzoxazole was dissolved in 3 ml of DMF. Under cooling with ice, 101 mg of bromoethyl acetate was added to the thus prepared solution, and the reaction was carried out for 1 hour at the same temperature and then for 84 hours at room temperature. The reaction solution was concentrated under a reduced pressure, and 5 ml of acetone was added to the resulting residue. The precipitate thus formed was collected by filtration, washed with acetone and then dried to obtain 167 mg of the title compound.

Workup

  1. additionwas added to the thus prepared solution
  2. waitfor 84 hours at room temperature
  3. concentrationThe reaction solution was concentrated under a reduced pressure, and 5 ml of acetone
  4. additionwas added to the resulting residue
  5. customThe precipitate thus formed
  6. filtrationwas collected by filtration
  7. washwashed with acetone
  8. customdried

Sources & evidence

ORD record
ord-638f6bee76004d01b2914a87f43bd8c3
Source dataset
uspto-grants-1997_05
Patent number
US05631257

Reaction notes

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