Bromoacetone → HCID 19047272, compound

HRID 1780662Notes

Reaction equation

HRID 1780662 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8]2[O:9][C:10]3[CH:16]=[CH:15][CH:14]=[CH:13][C:11]=3[N:12]=2)[CH2:4][CH2:3]1.[Br:17][CH2:18][C:19](=[O:21])[CH3:20]>CN(C=O)C>[Br-:17].[CH2:18]([N+:2]1([CH3:1])[CH2:3][CH2:4][N:5]([C:8]2[O:9][C:10]3[CH:16]=[CH:15][CH:14]=[CH:13][C:11]=3[N:12]=2)[CH2:6][CH2:7]1)[C:19]([CH3:20])=[O:21]

Participants

4

Reactant 2

HCID 11715BromoacetoneHCID 37945392-(4-methylpiperazino)-1,3-benzoxazole

Product 1

HCID 19047272HCID 19047272, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A 100 mg portion of 2-(4-methyl-1-piperazinyl)-benzoxazole was dissolved in 3 ml of DMF. Under cooling with ice, 95 mg of bromoacetone was added to the thus prepared solution, and the reaction was carried out for 1 hour at the same temperature and then for 60 hours at room temperature. The reaction solution was concentrated under a reduced pressure, and 5 ml of acetone was added to the resulting residue. The precipitate thus formed was collected by filtration, washed with acetone and then dried to obtain 119 mg of the title compound.

Workup

  1. additionwas added to the thus prepared solution
  2. waitfor 60 hours at room temperature
  3. concentrationThe reaction solution was concentrated under a reduced pressure, and 5 ml of acetone
  4. additionwas added to the resulting residue
  5. customThe precipitate thus formed
  6. filtrationwas collected by filtration
  7. washwashed with acetone
  8. customdried

Sources & evidence

ORD record
ord-5b0f592ce3e84f88844df8870de3f2ad
Source dataset
uspto-grants-1997_05
Patent number
US05631257

Reaction notes

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