1-(2-Hydroxyethyl)piperazine → HCID 17528475, compound

HRID 1780665Notes

Reaction equation

HRID 1780665 reaction equation
Cl[C:2]1[O:3][C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=1.[OH:11][CH2:12][CH2:13][N:14]1[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1>CN(C=O)C>[OH:11][CH2:12][CH2:13][N:14]1[CH2:19][CH2:18][N:17]([C:2]2[O:3][C:4]3[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=3[N:6]=2)[CH2:16][CH2:15]1

Participants

4

Reactant 2

HCID 76771-(2-Hydroxyethyl)piperazineHCID 119862-Chlorobenzoxazole

Product 1

HCID 17528475HCID 17528475, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A 300 mg portion of 2-chlorobenzoxazole was dissolved in 2 ml of DMF. Under cooling with ice, 279 mg of 1-(2 -hydroxyethyl)piperazine was added to the thus prepared solution, and the reaction was carried out for 1 hour at the same temperature and then for 24 hours at room temperature. The reaction solution was concentrated under a reduced pressure, and the resulting residue was dissolved in 100 ml of ethyl acetate and washed with sodium hydrogencarbonate aqueous solution (pH 8) and then with water. The resulting organic layer was dehydrated with sodium sulfate and concentrated under a reduced pressure to obtain 140 mg of the title compound.

Workup

  1. additionwas added to the thus prepared solution
  2. waitfor 24 hours at room temperature
  3. concentrationThe reaction solution was concentrated under a reduced pressure
  4. dissolutionthe resulting residue was dissolved in 100 ml of ethyl acetate
  5. washwashed with sodium hydrogencarbonate aqueous solution (pH 8)
  6. concentrationconcentrated under a reduced pressure

Sources & evidence

ORD record
ord-a13ddbcda7a84f818d275039a38e60f8
Source dataset
uspto-grants-1997_05
Patent number
US05631257

Reaction notes

Loading…