Methyl iodide → 1,1-Dimethyl-4-(benzoxazol-2-yl)homopiperazinium iodide

HRID 1780667Notes

Reaction equation

HRID 1780667 reaction equation
[CH3:1][N:2]1[CH2:8][CH2:7][CH2:6][N:5]([C:9]2[O:10][C:11]3[CH:17]=[CH:16][CH:15]=[CH:14][C:12]=3[N:13]=2)[CH2:4][CH2:3]1.[CH3:18][I:19]>O1CCCC1>[I-:19].[CH3:1][N+:2]1([CH3:18])[CH2:8][CH2:7][CH2:6][N:5]([C:9]2[O:10][C:11]3[CH:17]=[CH:16][CH:15]=[CH:14][C:12]=3[N:13]=2)[CH2:4][CH2:3]1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 105856212-(4-Methyl-1-homopiperazinyl)benzoxazole

Product 1

HCID 190472911,1-Dimethyl-4-(benzoxazol-2-yl)homopiperazinium iodide

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A 200 mg portion of 2-(4-methyl-1-homopiperazinyl)-benzoxazole was dissolved in 5 ml of tetrahydrofuran (THF). Under cooling with ice, 0.064 ml of methyl iodide was added to the thus prepared solution, and the reaction was carried out for 1 hour at the same temperature and then for 2 hours at room temperature. The reaction solution was concentrated under a reduced pressure, and 5 ml of acetone was added to the resulting residue. The precipitate thus formed was collected by filtration, washed with acetone and then dried to obtain 320 mg of the title compound.

Workup

  1. additionwas added to the thus prepared solution
  2. waitfor 2 hours at room temperature
  3. concentrationThe reaction solution was concentrated under a reduced pressure, and 5 ml of acetone
  4. additionwas added to the resulting residue
  5. customThe precipitate thus formed
  6. filtrationwas collected by filtration
  7. washwashed with acetone
  8. customdried

Sources & evidence

ORD record
ord-db9a4bd0f09d4b189a7e8cc0650286e6
Source dataset
uspto-grants-1997_05
Patent number
US05631257

Reaction notes

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