Allyl iodide → 1-Allyl-1-methyl-4-(benzoxazol-2-yl)homopiperazinium iodide

HRID 1780668Notes

Reaction equation

HRID 1780668 reaction equation
[CH3:1][N:2]1[CH2:8][CH2:7][CH2:6][N:5]([C:9]2[O:10][C:11]3[CH:17]=[CH:16][CH:15]=[CH:14][C:12]=3[N:13]=2)[CH2:4][CH2:3]1.[CH2:18]([I:21])[CH:19]=[CH2:20]>ClCCl>[I-:21].[CH2:18]([N+:2]1([CH3:1])[CH2:8][CH2:7][CH2:6][N:5]([C:9]2[O:10][C:11]3[CH:17]=[CH:16][CH:15]=[CH:14][C:12]=3[N:13]=2)[CH2:4][CH2:3]1)[CH:19]=[CH2:20]

Participants

4

Reactant 2

HCID 11166Allyl iodideHCID 105856212-(4-Methyl-1-homopiperazinyl)benzoxazole

Product 1

HCID 190472701-Allyl-1-methyl-4-(benzoxazol-2-yl)homopiperazinium iodide

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A 540 mg portion of 2-(4-methyl-1-homopiperazinyl)-benzoxazole was dissolved in 5 ml of dichloromethane. Under cooling with ice, 0.32 ml of allyl iodide was added to the thus prepared solution, and the reaction was carried out for 1 hour at the same temperature and then for 1 hour at room temperature. The reaction solution was concentrated under a reduced pressure, and 5 ml of acetone was added to the resulting residue. The precipitate thus formed was collected by filtration, washed with acetone and then dried to obtain 821 mg of the title compound.

Workup

  1. additionwas added to the thus prepared solution
  2. waitfor 1 hour at room temperature
  3. concentrationThe reaction solution was concentrated under a reduced pressure, and 5 ml of acetone
  4. additionwas added to the resulting residue
  5. customThe precipitate thus formed
  6. filtrationwas collected by filtration
  7. washwashed with acetone
  8. customdried

Sources & evidence

ORD record
ord-16dc647c696b4e44a938b7488794d2f2
Source dataset
uspto-grants-1997_05
Patent number
US05631257

Reaction notes

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