3-Nitrobenzaldehyde → HCID 19047699, compound

HRID 1780812Notes

Reaction equation

HRID 1780812 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][CH:11]=1)[CH:7]=O)([O-:3])=[O:2].[CH3:12][C:13]1[C:18]([CH3:19])=[CH:17][CH:16]=[CH:15][C:14]=1[NH:20]C1C=CC=CC=1>>[CH3:12][C:13]1[C:18]([CH3:19])=[CH:17][CH:16]=[CH:15][C:14]=1[NH:20][CH2:7][C:6]1[CH:5]=[C:4]([N+:1]([O-:3])=[O:2])[CH:11]=[CH:10][CH:9]=1

Participants

3

Reactant 2

HCID 74493-NitrobenzaldehydeHCID 14952469Mefenamic Acid Impurity 5（Mefenamic Acid EP Impurity E）

Product 1

HCID 19047699HCID 19047699, compound

Procedure

Starting with 3-nitrobenzaldehyde (0.50 g) and 2,3-dimethylphenylaniline (0.40 mL) the method described in Step 3. of Example 1 was used to prepare the above compound. NMR (300 MHz, CDCl3) δ 8.25 (1H, s), 8.12 (1H, d, J=7 Hz), 7.72 (1H, d, J=7 Hz), 7.50 (1H, t, J=8 Hz), 6.95 (1H, t, J=8 Hz), 6.62 (1H, d, J=7 Hz), 6.36 (1H, d, J=7 Hz), 4.50 (2H, s), 4.09 (1H, s), 2.30 (3H, s), 2.13 (3H, s).

Workup

  1. customto prepare the above compound

Sources & evidence

ORD record
ord-e8ede04f1bf946d3acc581621f5cb4e4
Source dataset
uspto-grants-1997_05
Patent number
US05631280

Reaction notes

Loading…