Hydrogen Bromide → 1-(Bromomethyl)-4-(trifluoromethyl)benzene

HRID 1780887Notes

Reaction equation

HRID 1780887 reaction equation
[F:1][C:2]([F:12])([F:11])[C:3]1[CH:10]=[CH:9][C:6]([CH2:7]O)=[CH:5][CH:4]=1.O.[BrH:14]>>[F:1][C:2]([F:12])([F:11])[C:3]1[CH:10]=[CH:9][C:6]([CH2:7][Br:14])=[CH:5][CH:4]=1

Participants

4

Reactant 3

HCID 260Hydrogen BromideHCID 962WaterHCID 676844-(Trifluoromethyl)benzenemethanol

Product 1

HCID 1230621-(Bromomethyl)-4-(trifluoromethyl)benzene

Procedure

A mixture of 5.5 g of p-trifluoromethyl-benzyl alcohol in 50 mL of 48% HBr was heated on a steam-bath for 6 h with stirring, and cooled. Water (100 mL) was added to the above mixture, and the aqueous layer was extracted with ether, and the organic layer was concentrated in vacuo to afford 4.8 g of p-trifluoromethyl-benzyl bromide.

Workup

  1. temperaturewas heated on a steam-bath for 6 h
  2. temperaturecooled
  3. extractionthe aqueous layer was extracted with ether
  4. concentrationthe organic layer was concentrated in vacuo

Sources & evidence

ORD record
ord-2908edd54495424abec5e4bd0e838134
Source dataset
uspto-grants-1997_05
Patent number
US05631264

Reaction notes

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