反应详情

A mixture of 0.6 g (2.5 mmol) of 1-(2-pyridyl)-1-[2,6-di(hydroxymethyl)-phenyl]methanol and 10 ml of POCl3 was refluxed with 30 stirring for 4 hours. The mixture was cooled, poured onto ice, stirred and treated with a 20% sodium perchlorate solution. The resulting mixture was filtered, the resulting solid was washed with water, and dried to afford 0.58 g of 10-chloromethyl-benzo[b]quinolizinium perchlorate (Formula II: R1 =R2 =H; R7 =10-CH2Cl; X- =ClO4-).

1. temperaturewas refluxed with 30 stirring for 4 hours
2. temperatureThe mixture was cooled
3. additionpoured onto ice
4. filtrationThe resulting mixture was filtered
5. washthe resulting solid was washed with water
6. customdried