反应详情

温度

65 °C

A mixture of 2 g of (3aRS, 4RS, 5RS, 7aRS)-2-benzyl-7,7-diphenyl-4-(2-methoxyphenyl)perhydro-4,5-isoindolediol and 50 cm3 of ethanol is heated to 65° C. with stirring; 0.65 g of 20% palladium hydroxide on charcoal is added, and the reaction mixture is then hydrogenated, with stirring, at a temperature of 65° C. and at atmospheric pressure. After reaction for 1 hour, the theoretical volume of hydrogen has been absorbed; the reaction mixture is filtered and then concentrated to dryness under reduced pressure (2.7 kPa). The residue is crystallized in 10. cm3 of isopropyl ether. 1.45 g of (3aRS,4RS,5RS,7aRS)-7,7-diphenyl-4-(2-methoxyphenyl)perhydro-4,5-isoindolediol are obtained, melting at 230° C.

1. stirringhydrogenated, with stirring, at a temperature of 65° C. and at atmospheric pressure
2. customAfter reaction for 1 hour
3. customthe theoretical volume of hydrogen has been absorbed
4. filtrationthe reaction mixture is filtered
5. concentrationconcentrated to dryness under reduced pressure (2.7 kPa)
6. customThe residue is crystallized in 10