HRID1780971

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2795386

2-(1-Naphthyl)Ethanoyl Chloride

C12H9ClO

结构：COc1ccccc1C1(O)C(O)CC(c2ccccc2)(c2ccccc2)C2CNCC21

HCID19047650

未命名化合物

PRODUCTS

生成物

结构：COc1ccccc1C1(O)C(O)CC(c2ccccc2)(c2ccccc2)C2CN(C(=O)Cc3cccc4ccccc34)CC21

HCID67719299

未命名化合物

收率 45.9%

PROCEDURE

实验过程

By working according to the procedure of Example A, starting from 0.62 g of (3aRS,4RS,5RS,7aRS)-7,7-diphenyl-4-(2-methoxyphenyl)perhydro-4,5-isoindolediol and 0.35 g of 1-naphthylacetyl chloride, 0.4 g of (3aRS,4RS,5RS,7aRS)-7,7-diphenyl-4-(2methoxyphenyl)-2-[(1-naphthyl)acetyl]perhydro-4,5-isoindolediol is obtained, melting at 188°-190° C.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f702a20ae3d74a158601fb61cb6aa32b
来源数据集: uspto-grants-1997_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05631279
来源说明: uspto-grants-1997_05

反应 SMILES

[C:1]1([C:7]2([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)[CH:15]3[CH:11]([CH2:12][NH:13][CH2:14]3)[C:10]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[O:23][CH3:24])([OH:16])[CH:9]([OH:25])[CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:32]1([CH2:42][C:43](Cl)=[O:44])[C:41]2[C:36](=[CH:37][CH:38]=[CH:39][CH:40]=2)[CH:35]=[CH:34][CH:33]=1>>[C:26]1([C:7]2([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)[CH:15]3[CH:11]([CH2:12][N:13]([C:43](=[O:44])[CH2:42][C:32]4[C:41]5[C:36](=[CH:37][CH:38]=[CH:39][CH:40]=5)[CH:35]=[CH:34][CH:33]=4)[CH2:14]3)[C:10]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[O:23][CH3:24])([OH:16])[CH:9]([OH:25])[CH2:8]2)[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1