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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1780971Generated: October 25, 2026

2-(Naphthalen-1-yl)acetyl chloride → (3aRS,4RS,5RS,7aRS)-7,7-diphenyl-4-(2methoxyphenyl)-2-[(1-naphthyl)acetyl]perhydro-4,5-isoindolediol

https://huagongshe.com/reaction/1780971

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(Naphthalen-1-yl)acetyl chlorideHCID 2795386—
Reactant(3aRS,4RS,5RS,7aRS)-7,7-diphenyl-4-(2-methoxyphenyl)perhydro-4,5-isoindolediolHCID 19047650—
Product(3aRS,4RS,5RS,7aRS)-7,7-diphenyl-4-(2methoxyphenyl)-2-[(1-naphthyl)acetyl]perhydro-4,5-isoindolediolHCID 6771929945.9%

Reaction Steps

By working according to the procedure of Example A, starting from 0.62 g of (3aRS,4RS,5RS,7aRS)-7,7-diphenyl-4-(2-methoxyphenyl)perhydro-4,5-isoindolediol and 0.35 g of 1-naphthylacetyl chloride, 0.4 g of (3aRS,4RS,5RS,7aRS)-7,7-diphenyl-4-(2methoxyphenyl)-2-[(1-naphthyl)acetyl]perhydro-4,5-isoindolediol is obtained, melting at 188°-190° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05631279
Source datasetuspto-grants-1997_05
ORD IDord-f702a20ae3d74a158601fb61cb6aa32b
Source noteuspto-grants-1997_05