Sodium Carbonate → HCID 19048319, compound

HRID 1781111Notes

Reaction equation

HRID 1781111 reaction equation
[CH3:1][O:2][CH:3](Cl)[C:4]([NH:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)=[O:5].C(=O)([O-])[O-:15].[Na+].[Na+].CN1CCCC1=O>O>[CH3:1][O:2][CH:3]([OH:15])[C:4]([NH:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)=[O:5]

Participants

5

Reactant 3

HCID 10340Sodium CarbonateHCID 13387N-methyl-2-pyrrolidoneHCID 19048317HCID 19048317, compound

Product 1

HCID 19048319HCID 19048319, compoundYield 70%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

In a 250 ml flask, 10 g (0.05 mol) of 2-methoxy-chloroacetanilide (prepared from chloroacetyl chloride and 2-methoxyaniline) and 6 g (0.55 mol) of sodium carbonate are heated at 100° C. in a solvent mixture of 100 ml of N-methylpyrrolidone and 70 ml of water. A GC check after a reaction time of 6 hours reveals a yield of 70% of 2-methoxy-hydroxyacetanilide and 5.5% of 2-methoxydiglycolanilide.

Workup

  1. customafter a reaction time of 6 hours

Sources & evidence

ORD record
ord-2920997f3a2d4e0aba7221e2957419ed
Source dataset
uspto-grants-1997_05
Patent number
US05631403

Reaction notes

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