Neopentyl alcohol → HCID 9942177, compound

Temperature

100 °C

To a mixed solution of neopentyl alcohol (500 ml, 5.7 mol) and dimethyl carbonate (2070 g, 23.0 mol), a 28% sodium methoxide/methanol solution (11 g) was added and the mixture was heated to 100° C. to remove the methanol by evaporation for 6 hours. After allowing the mixture to cool to room temperature, an aqueous solution of ammonium chloride was added to the mixture and the mixture was shaken to remove the sodium methoxide. The organic layer was washed with water, dried and distilled to give methyl neopentyl carbonate as a colorless liquid (450 g, yield 55%). The chemical structure of the produced compound was determined based on the IR and NMR absorbance spectra shown in FIG. 1 and FIG. 2 respectively and the mass spectrometry spectrum (M/e=146).

1. customto remove the methanol
2. customby evaporation for 6 hours
3. temperatureto cool to room temperature
4. additionan aqueous solution of ammonium chloride was added to the mixture
5. customto remove the sodium methoxide
6. washThe organic layer was washed with water
7. customdried
8. distillationdistilled

ORD record

ord-9001260bcc10489c8c8b22567801e0cf

Source dataset

uspto-grants-1997_05

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05633099