Sodium Hydroxide → HCID 23195105, compound

HRID 1781249Notes

Reaction equation

HRID 1781249 reaction equation
[CH2:1]([N:4]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[N:7]=[C:6]([NH:14]C(OC(C)(C)C)=O)[C:5]1=[O:22])[CH2:2][CH3:3].[OH-].[Na+]>CO.Cl>[CH2:1]([N:4]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[N:7]=[C:6]([NH2:14])[C:5]1=[O:22])[CH2:2][CH3:3]

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 19045874HCID 19045874, compound

Product 1

HCID 23195105HCID 23195105, compoundYield 95.7%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 887MethanolSolvent

Procedure

A solution of 7.12 grams (0.0234 mol) of carbamate 3 in 50 ml of methanol and 35 ml of 6N hydrochloric acid is stirred at room temperature for 4 hours. The solution is neutralized, with cooling, by addition of 6N sodium hydroxide. The crystals formed are filtered off, washed with water and dried at 50° C. 4.55 g (yield 95%) of compound 4 are thus obtained in the form of a white powder.

Workup

  1. customThe crystals formed
  2. filtrationare filtered off
  3. washwashed with water
  4. customdried at 50° C

Sources & evidence

ORD record
ord-f82ffc1d185d4762a9b078e4e9fabb07
Source dataset
uspto-grants-1997_05
Patent number
US05633255

Reaction notes

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