Hydrochloric Acid → HCID 19766244, compound

HRID 1781352Notes

Reaction equation

HRID 1781352 reaction equation
[N+:1]([C:4]1[S:26][C:7]2[S:8][C:9]3([CH2:17][CH2:16][N:15](C(=O)C4C=CC=CC=4)[CH2:14][CH2:13]3)[CH2:10][C:11](=[O:12])[C:6]=2[CH:5]=1)([O-:3])=[O:2].[ClH:27]>CO>[ClH:27].[N+:1]([C:4]1[S:26][C:7]2[S:8][C:9]3([CH2:13][CH2:14][NH:15][CH2:16][CH2:17]3)[CH2:10][C:11](=[O:12])[C:6]=2[CH:5]=1)([O-:3])=[O:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 19045268HCID 19045268, compound

Product 1

HCID 19766244HCID 19766244, compoundYield 73%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A suspension of 1.1 g (2.9 mmol) Of 2'-nitro-1-(benzoyl)spiro(piperidine-4,6'-(6H)thieno[2,3-b]thiopyran)-4'(5'H)-one in 25 mL methanol was treated with 25 ml of 6N HCl and heated to reflux for 3 days. The reaction was cooled to ambient temperature and the solid collected and dried in vacuo, to give 680 mg (73%) of the product, mp=262° C.

Workup

  1. temperatureheated
  2. temperatureto reflux for 3 days
  3. customthe solid collected
  4. customdried in vacuo

Sources & evidence

ORD record
ord-f65db27a2d674478893e33364067f34e
Source dataset
uspto-grants-1997_05
Patent number
US05633247

Reaction notes

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