Hydrochloric Acid → HCID 70068021, compound

HRID 1781353Notes

Reaction equation

HRID 1781353 reaction equation
C([N:9]1[CH2:23][CH2:22][C:12]2([S:17][C:16]3[S:18][CH:19]=[CH:20][C:15]=3[C:14](=[O:21])[CH2:13]2)[CH2:11][CH2:10]1)(=O)C1C=CC=CC=1.[ClH:24]>C(O)C>[ClH:24].[S:18]1[C:16]2[S:17][C:12]3([CH2:22][CH2:23][NH:9][CH2:10][CH2:11]3)[CH2:13][C:14](=[O:21])[C:15]=2[CH:20]=[CH:19]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67724163HCID 67724163, compound

Product 1

HCID 70068021HCID 70068021, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 14 g (40.99 mmol) of 1-benzoylspiro(piperidine-4,6'-(6H)thieno[2,3-b]thiopyran)-4'-(5'H)-one in 150 ml of ethanol was treated with 50 ml of 6N HCl and heated at reflux for 2 days. The reaction was cooled to room temperature and the solid collected by filtration. The solid was dried overnight in vacuo to give 9.03 g of the product. mp=280° C.

Workup

  1. temperatureheated
  2. temperatureat reflux for 2 days
  3. filtrationthe solid collected by filtration
  4. customThe solid was dried overnight in vacuo

Sources & evidence

ORD record
ord-ec57176989cf4ac985f33c1e593bb213
Source dataset
uspto-grants-1997_05
Patent number
US05633247

Reaction notes

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