Hydrochloric Acid → 2-[4-(Aminomethyl)phenyl]ethan-1-ol

HRID 1781392Notes

Reaction equation

HRID 1781392 reaction equation
[C:1]([C:3]1[CH:11]=[CH:10][C:6]([CH2:7][CH2:8][OH:9])=[CH:5][CH:4]=1)#[N:2].Cl>C(O)C.[Pd]>[OH:9][CH2:8][CH2:7][C:6]1[CH:10]=[CH:11][C:3]([CH2:1][NH2:2])=[CH:4][CH:5]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 28008154-(2-Hydroxyethyl)benzonitrile

Product 1

HCID 226014582-[4-(Aminomethyl)phenyl]ethan-1-ol

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of 0.74 g (0.005 mol) of p-cyanophenethyl alcohol in 50 ml of ethanol containing 10 ml of concentrated hydrochloric acid was hydrogenated at 30 psi using 0.1 g 5% Pd/C for 72 hours. The catalyst was removed by filtration and the solvent was removed under reduced pressure.

Workup

  1. customfor 72 hours
  2. customThe catalyst was removed by filtration
  3. customthe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-318a0d649152403aa70213f1e775d186
Source dataset
uspto-grants-1997_05
Patent number
US05633247

Reaction notes

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