HRID1781522

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID77590

Ethane, 1-(chloromethoxy)-2-methoxy-

C4H9ClO2

HCID81531

Diisopropylethylamine

C8H19N

结构：COC(=O)CC/C(C)=C/Cc1c(O)c2c(c(C)c1OC)COC2=O

HCID6478685

Methyl (4E)-6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-4-hexenoate

C18H22O6

PRODUCTS

生成物

$结构：COCCOCOc1c(C/C=C(\C)CCC(=O)OC)c(OC)c(C)c2c1C(=O)OC2$

HCID10342183

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

To methyl (E)-6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxoisobenzofuran-5-yl)-4-methyl-4-hexenoate (61.0 g) in methylene chloride (1000 ml) at 0° C. was added diisopropylethylamine (30.4 g) and methoxyethoxymethyl chloride (29.2 g). After 31/2 hours the solution was washed with dilute hydrochloric acid, dried and evaporated to give methyl (E)-6-(1,3-dihydro-6-methoxy-4-methoxyethoxymethoxy-7-methyl-3-oxoisobenzofuran-5-yl) -4-methyl-4-hexenoate as an oil.

WORKUP

后处理

washAfter 31/2 hours the solution was washed with dilute hydrochloric acid
customdried
customevaporated