HCID 86750886, compound → HCID 70303321, compound

HRID 1781533Notes

Reaction equation

HRID 1781533 reaction equation
[OH:1][C:2]1[C:10]([CH2:11]/[CH:12]=[C:13](\[CH3:23])/[CH:14]([O:21][CH3:22])[CH2:15][C:16]([O:18]CC)=[O:17])=[C:9]([O:24][CH3:25])[C:8]([CH3:26])=[C:7]2[C:3]=1[C:4](=[O:27])[O:5][CH2:6]2>CCCCCC.C(Cl)Cl>[OH:1][C:2]1[C:10]([CH2:11]/[CH:12]=[C:13](\[CH3:23])/[CH:14]([O:21][CH3:22])[CH2:15][C:16]([OH:18])=[O:17])=[C:9]([O:24][CH3:25])[C:8]([CH3:26])=[C:7]2[C:3]=1[C:4](=[O:27])[O:5][CH2:6]2

Participants

3

Reactant 1

HCID 86750886HCID 86750886, compound

Product 1

HCID 70303321HCID 70303321, compound

Reagents, catalysts & solvents 1

HCID 21226440Methylenechloride HexaneSolvent

Procedure

By following the procedure of Example ZA-6A and substituting methyl (E)-6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxoisobenzofuran-5-yl) 2,4-dimethyl-4-hexenoate with ethyl (E)-6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxoisobenzofuran-5-yl)-3-methoxy-4-methyl-4-hexenoate and the corresponding compounds of Formula I-ZA-M1 prepared as described in Part A above, there are obtained (E)-6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxoisobenzofuran-5-yl)-3-methoxy-4-methyl-4-hexenoic acid, m.p. 133°-135° C. (hexane/methylene chloride) and the corresponding compounds of Formula I-ZA-M2 as identified in the following table.

Workup

  1. customthe corresponding compounds of Formula I-ZA-M1 prepared

Sources & evidence

ORD record
ord-78e66f63118845168ca11d31beeffab3
Source dataset
uspto-grants-1997_05
Patent number
US05633279

Reaction notes

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