Methylamine → HCID 178463701, compound

HRID 1781589Notes

Reaction equation

HRID 1781589 reaction equation
[Cl:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][N:9]([CH2:16][CH3:17])[C:10](=[N:13][C:14]#[N:15])SC)=[CH:4][CH:3]=1.[CH3:18][NH2:19]>C(#N)C>[Cl:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][N:9]([CH2:16][CH3:17])[C:10]([NH:19][CH3:18])=[N:13][C:14]#[N:15])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 15171094HCID 15171094, compound

Product 1

HCID 178463701HCID 178463701, compoundYield 81.4%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

To a mixture of 0.42 g of 1-(6-chloro-3-pyridylmethyl)-3-cyano-1-ethyl-2-methylisothiourea and 5 ml of acetonitrile was added each 0.5 g of 40% methylamine aqueous solution at an hour interval in total six time (3.0 g), while refluxing and stirring. The reaction mixture was stirred for 6 hours in total. Then, the mixture was concentrated to afford 0.32 g of 1-(6-chloro-3-pyridylmethyl)-2-cyano-1-ethyl-3-methylguanidine (Compound No. 3).

Workup

  1. temperaturewhile refluxing
  2. stirringThe reaction mixture was stirred for 6 hours in total
  3. concentrationThen, the mixture was concentrated

Sources & evidence

ORD record
ord-ea67113aecf847ec8fb13bda32202f05
Source dataset
uspto-grants-1997_05
Patent number
US05633375

Reaction notes

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