Hydrochloric Acid → HCID 54725880, compound

Participants

Reaction Steps

The 7-chloro-4-hydroxy-3-(methoxycarbonylmethylthio)-2(1H)-quinolone obtained in accordance with Example 7 is dissolved in 2N sodium hydroxide solution and left to stand for 2 hours at room temperature. The reaction mixture is adjusted to pH 2 with 4N hydrochloric acid and the resulting suspension is filtered. The colourless crystals are dried under a high vacuum at 60°. 7-chloro-4-hydroxy-3-(carboxymethylthio)-2(1H)-quinolone is obtained in the form of pure crystals having a melting point of 288° (decomp.).

Provenance & Evidence