Hydrochloric Acid → HCID 54725880, compound

HRID 1781623Notes

Reaction equation

HRID 1781623 reaction equation
[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([OH:19])=[C:7]([S:13][CH2:14][C:15]([O:17]C)=[O:16])[C:8](=[O:12])[NH:9]2)=[CH:4][CH:3]=1.Cl>[OH-].[Na+]>[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([OH:19])=[C:7]([S:13][CH2:14][C:15]([OH:17])=[O:16])[C:8](=[O:12])[NH:9]2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 54733740HCID 54733740, compound

Product 1

HCID 54725880HCID 54725880, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

The 7-chloro-4-hydroxy-3-(methoxycarbonylmethylthio)-2(1H)-quinolone obtained in accordance with Example 7 is dissolved in 2N sodium hydroxide solution and left to stand for 2 hours at room temperature. The reaction mixture is adjusted to pH 2 with 4N hydrochloric acid and the resulting suspension is filtered. The colourless crystals are dried under a high vacuum at 60°. 7-chloro-4-hydroxy-3-(carboxymethylthio)-2(1H)-quinolone is obtained in the form of pure crystals having a melting point of 288° (decomp.).

Workup

  1. waitleft
  2. filtrationthe resulting suspension is filtered
  3. customThe colourless crystals are dried under a high vacuum at 60°

Sources & evidence

ORD record
ord-f0092dd1c9064d60bb8e8f2d74dc4e96
Source dataset
uspto-grants-1997_05
Patent number
US05633379

Reaction notes

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