Hydrazine hydrate (1:1) → HCID 178526459, compound

HRID 1781873Notes

Reaction equation

HRID 1781873 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([CH:13]=[C:14]([N+:17]([O-:19])=[O:18])[C:15]=1[OH:16])[C:5]([CH2:7][C:8](OCC)=[O:9])=O.O.[NH2:21][NH2:22]>C(O)C>[OH:9][C:8]1[NH:22][N:21]=[C:5]([C:4]2[CH:3]=[C:2]([OH:1])[C:15]([OH:16])=[C:14]([N+:17]([O-:19])=[O:18])[CH:13]=2)[CH:7]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 21459116Ethyl(3,4-dihydroxy-5-nitrobenzoyl)acetate

Product 1

HCID 178526459HCID 178526459, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2.0 g of ethyl (3,4-dihydroxy-5-nitrobenzoyl)acetate are suspended in 50 ml of ethanol. After treatment with 0.4 g of hydrazine hydrate the mixture is held at the reflux temperature for 16 hours. After distillation of the solvent, the residue is held at the boiling temperature for 5 minutes with 50 ml of ethyl acetate. The separated precipitate is filtered under suction and the filtrate is concentrated to 10 ml. The crystals, which separate in the cold, are filtered under suction. There is obtained 5-(5-hydroxypyrazol-3-yl)-3-nitropyrocatechol in form of orange crystals of m.p. 228° (dec.).

Workup

  1. distillationAfter distillation of the solvent
  2. filtrationThe separated precipitate is filtered under suction
  3. concentrationthe filtrate is concentrated to 10 ml
  4. customThe crystals, which separate in the cold,
  5. filtrationare filtered under suction

Sources & evidence

ORD record
ord-6445255240324e9d8447953c0b0e269b
Source dataset
uspto-grants-1997_05
Patent number
US05633371

Reaction notes

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