Tris(hydroxymethyl)aminomethane → HCID 67414222, compound

HRID 1782001Notes

Reaction equation

HRID 1782001 reaction equation
[CH2:1]([N:8]1[C:19](=[O:20])[C:18]2[CH:21]=[CH:22][CH:23]=[CH:24][C:17]=2[O:16][C:10]2([CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH:25]1([N:30]=[C:31]=[O:32])[CH2:29][CH2:28][CH2:27][CH2:26]1.C(O)C(N)(CO)CO>ClC(Cl)C>[CH2:1]([N:8]1[C:19](=[O:20])[C:18]2[CH:21]=[CH:22][CH:23]=[CH:24][C:17]=2[O:16][C:10]2([CH2:11][CH2:12][N:13]([C:31]([NH:30][CH:25]3[CH2:29][CH2:28][CH2:27][CH2:26]3)=[O:32])[CH2:14][CH2:15]2)[CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 6503Tris(hydroxymethyl)aminomethaneHCID 643500Cyclopentyl IsocyanateHCID 67411631HCID 67411631, compound

Product 1

HCID 67414222HCID 67414222, compound

Reagents, catalysts & solvents 1

HCID 63651,1-DichloroethaneSolvent

Conditions

Temperature
25 °C

Procedure

To a solution of the compound prepared in Example 30 (0.010 mmol) in dichloroethane (0.7 mL) was added cyclopentylisocyanate (0.020 mmol), the mixture was stirred overnight at 25° C. To the reaction mixture was added PS-trisamine (Argonaut, product number 800229, loading; 4.36 mmol/g) (6.9 mg). After stirring overnight at 25° C., the mixture was filtered and the filtrate was concentrated to give the compound of the present invention having the following physical data.

Workup

  1. stirringAfter stirring overnight at 25° C.
  2. filtrationthe mixture was filtered
  3. concentrationthe filtrate was concentrated
  4. customto give the compound of the present invention

Sources & evidence

ORD record
ord-ee60cafbad574b10a5cdb22bc2c72c38
Source dataset
uspto-grants-2009_03
Patent number
US07498323B2

Reaction notes

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