反应详情

The chloroquinolone (7a) in dry DMF (8 mL) was cooled in ice and phosphorus tribromide (0.7 mL) added drop-wise, and the mixture was stirred, with ice-cooling for 30 minutes then allowed to warm to room temperature and stirred for a further 2 hours. It was cooled in ice and sodium carbonate solution was added and the solid was collected, washed well with water, and dried in vacuo, to afford a pale yellow solid (1.65 g).

1. temperaturecooling for 30 minutes
2. stirringstirred for a further 2 hours
3. temperatureIt was cooled in ice
4. customthe solid was collected
5. washwashed well with water
6. customdried in vacuo