Chloroform → HCID 69058987, compound

HRID 1782020Notes

Reaction equation

HRID 1782020 reaction equation
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([CH2:11][CH2:12][N:13]2[CH2:18][CH2:17][CH:16]([NH:19]C(=O)OC(C)(C)C)[CH2:15][CH2:14]2)=[CH:3][CH:2]=1.C(Cl)(Cl)[Cl:28]>Cl.O1CCOCC1>[ClH:28].[ClH:28].[ClH:28].[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([CH2:11][CH2:12][N:13]2[CH2:14][CH2:15][CH:16]([NH2:19])[CH2:17][CH2:18]2)=[CH:3][CH:2]=1

Participants

5

Reactant 2

HCID 6212ChloroformHCID 86603854HCID 86603854, compound

Product 1

HCID 69058987HCID 69058987, compoundYield 100%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 312751,4-DioxaneSolvent

Procedure

1,1-dimethylethyl {1-[2-(4-quinolinyl)ethyl]-4-piperidinyl}carbamate (9a) (278 mg) was dissolved in chloroform and diluted with 4N HCl in dioxane solution. After stirring two hours, the reaction mixture was evaporated to dryness to afford the product as a solid (180 mg, 100%).

Workup

  1. customthe reaction mixture was evaporated to dryness

Sources & evidence

ORD record
ord-60614bbfc0554c2f9387e571239d1365
Source dataset
uspto-grants-2009_03
Patent number
US07498326B2

Reaction notes

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