1,8-Diazabicyclo(5.4.0)undec-7-ene → HCID 69080600, compound

HRID 1782039Notes

Reaction equation

HRID 1782039 reaction equation
N12CCCN=C1CCCCC2.[Cl:12][C:13]1[CH:22]=[C:21]2[C:16]([C:17](=[O:29])[CH:18]([C:26]([OH:28])=[O:27])[C:19](=[O:25])[N:20]2[CH2:23][CH3:24])=[CH:15][C:14]=1[NH:30][N:31]1[C:35]([CH3:36])=[CH:34][CH:33]=[C:32]1[CH3:37].[C:38]([O:44][CH2:45]Cl)(=[O:43])[C:39]([CH3:42])([CH3:41])[CH3:40]>C(#N)C>[Cl:12][C:13]1[CH:22]=[C:21]2[C:16]([C:17](=[O:29])[CH:18]([C:26]([O:28][CH2:45][O:44][C:38](=[O:43])[C:39]([CH3:42])([CH3:41])[CH3:40])=[O:27])[C:19](=[O:25])[N:20]2[CH2:23][CH3:24])=[CH:15][C:14]=1[NH:30][N:31]1[C:35]([CH3:36])=[CH:34][CH:33]=[C:32]1[CH3:37]

Participants

5

Reactant 3

HCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 87885Chloromethyl pivalateHCID 69081749HCID 69081749, compound

Product 1

HCID 69080600HCID 69080600, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

18 μl of 1,8-diazabicyclo[5.4.0]undec-7-ene were added to a solution of 21 mg of 7-chloro-6-(2,5-dimethylpyrrol-1-ylamino)-1-ethyl-4-oxo-1,4-dihydroquinolonecarboxylic acid (Example 36) in 3 ml of acetonitrile and stirred at room temperature for 30 minutes. Then 36 μl of chloromethyl pivalate were added, and reaction was allowed to take place at room temperature for 5 days. The resulting precipitate was filtered off with suction to afford 3.3 mg of pure product.

Workup

  1. customreaction
  2. customat room temperature
  3. customfor 5 days
  4. filtrationThe resulting precipitate was filtered off with suction

Sources & evidence

ORD record
ord-eb60650bae2546fa97103e49e3b80b1b
Source dataset
uspto-grants-2009_03
Patent number
US07498341B2

Reaction notes

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