反应详情

A mixture of (5R)-3-(3-fluoro-4-iodophenyl)-5-azidomethyl-1,3-oxazolidin-2-one (10 g, 28 mmol) and propargyl alcohol (3.2 mL, 56 mmol) in acetonitrile (80 mL) was treated with CuI (526 mg, 2.8 mmol) and then stirred overnight. The solidified reaction mixture was extracted with ethyl acetate:acetonitrile, washed with water, and dried over magnesium sulfate, and then evaporated under reduced pressure to give a crude product sufficiently pure for further use (12.3 g, quantitative).

1. customThe solidified reaction mixture
2. extractionwas extracted with ethyl acetate
3. washacetonitrile, washed with water
4. dry with materialdried over magnesium sulfate
5. customevaporated under reduced pressure