5-Amino-3-methyl-1,2-oxazole-4-carboxamide → HCID 54757117, compound
Reaction equation
[NH2:1][C:2]1[O:6][N:5]=[C:4]([CH3:7])[C:3]=1[C:8]([NH2:10])=[O:9]>C(OC(=O)CCC)(=O)CCC.CCCCCC>[C:2]([NH:1][C:2]1[O:6][N:5]=[C:4]([CH3:7])[C:3]=1[C:8]([NH2:10])=[O:9])(=[O:6])[CH2:3][CH2:4][CH3:7]Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Conditions
- Temperature
- 150 °C
Procedure
A mixture of 5-amino-3-methyl-isoxazole-4-carboxylic acid amide (2 g, 14.18 mmol) in 10 ml of butyric anhydride was stirred at 150° C. for 0.5-1 h. The brown solution was diluted with hexane (100 ml) and cooled to room temperature. The solid crushed out from the mixture was filtered and washed with hexane, dried in vacuo. The title amide (2.6 g) was obtained as white solid.
Workup
- temperaturecooled to room temperature
- customThe solid crushed out from the mixture
- filtrationwas filtered
- washwashed with hexane
- customdried in vacuo
Sources & evidence
- ORD record
- ord-63f611e8c256424799d887f9799d5c73
- Source dataset
- uspto-grants-2009_03
- Patent number
- US07498333B2
Reaction notes
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