Hydrogen chloride-ethyl acetate → HCID 86620793, compound

HRID 1782360Notes

Reaction equation

HRID 1782360 reaction equation
C(O[C:6](=O)[N:7]([CH2:9][C:10]1[CH:14]=[C:13]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[N:12]([S:21]([C:24]2[C:25]([Cl:30])=[N:26][CH:27]=[CH:28][CH:29]=2)(=[O:23])=[O:22])[CH:11]=1)C)(C)(C)C.C(OCC)(=O)C.Cl>C(OCC)(=O)C>[ClH:30].[Cl:30][C:25]1[C:24]([S:21]([N:12]2[C:13]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)=[CH:14][C:10]([CH2:9][NH:7][CH3:6])=[CH:11]2)(=[O:22])=[O:23])=[CH:29][CH:28]=[CH:27][N:26]=1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 86620795HCID 86620795, compound

Product 1

HCID 86620793HCID 86620793, compoundYield 96.1%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a solution (3 mL) of tert-butyl{[1-(2-chloro-3-pyridinesulfonyl)-5-phenyl-1H-pyrrol-3-yl]methyl}methylcarbamate (70 mg) in ethyl acetate was added a 4 mol/L hydrogen chloride-ethyl acetate solution (1 mL), and the mixture was stirred at room temperature for 3 hr. The solvent was evaporated under reduced pressure, and the residue was crystallized from ethanol-ethyl acetate to give the title compound (yield 29 mg, 49%).

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. customthe residue was crystallized from ethanol-ethyl acetate

Sources & evidence

ORD record
ord-00c09674435b450e97fbf7f3f21188ed
Source dataset
uspto-grants-2009_03
Patent number
US07498337B2

Reaction notes

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