Bicarbonate Ion → HCID 86593474, compound

HRID 1782389Notes

Reaction equation

HRID 1782389 reaction equation
[As:1]([C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10]([CH2:12]SCCC(N[C@H](C(O)=O)CCC(O)=O)=O)=[O:11])=[CH:5][CH:4]=1)=[O:2].[SH:28][CH2:29][CH2:30][C:31]([NH:33][C@@H:34]1[C@@H:40]([OH:41])[C@H:39]([OH:42])[C@@H:38]([CH2:43][OH:44])[O:37][CH:35]1[OH:36])=[O:32].[Na].[Na].C(=O)(O)[O-].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>CS(C)=O>[As:1]([C:3]1[CH:4]=[CH:5][C:6]([NH:9][C:10]([CH2:12][S:28][CH2:29][CH2:30][C:31]([NH:33][C@@H:34]2[C@@H:40]([OH:41])[C@H:39]([OH:42])[C@@H:38]([CH2:43][OH:44])[O:37][CH:35]2[OH:36])=[O:32])=[O:11])=[CH:7][CH:8]=1)=[O:2]

Participants

6

Reactant 4

HCID 769Bicarbonate IonHCID 11776TriphenylphosphineHCID 23535375HCID 23535375, compoundHCID 86593475HCID 86593475, compound

Product 1

HCID 86593474HCID 86593474, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent2×

Procedure

The procedure used was the same as for N-(3-(4-arsenosophenylcarbamoylmethylthio)propanoyl)-L-glutamic acid, using 3.00 mL (210 μmol) of 70.0 mM BRAO in DMSO, the disulfide of disodium N-(3-mercaptopropanoyl)-D-glucosamine (0.67 g), 0.5 M bicarbonate buffer, pH 9 (11.96 mL, 600 mmol), and 0.69 M triphenylphosphine in DMSO (1.9 mL, 1.3 mmol). The active concentration of trivalent arsenic was found to be 13.5 mM (11.0 mL of solution).

Workup

  1. concentrationThe active concentration of trivalent arsenic

Sources & evidence

ORD record
ord-fade2171f5ec4ebca010a1abc225720a
Source dataset
uspto-grants-2009_03
Patent number
US07498406B2

Reaction notes

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