2-Bromoethyl methyl ether → HCID 11633398, compound

HRID 1782442Notes

Reaction equation

HRID 1782442 reaction equation
[N:1]12[CH2:8][CH2:7][C:4]([C:9]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)[OH:10])([CH2:5][CH2:6]1)[CH2:3][CH2:2]2.[CH3:23][O:24][CH2:25][CH2:26][Br:27]>CC#N>[Br-:27].[OH:10][C:9]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)([C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1)[C:4]12[CH2:5][CH2:6][N+:1]([CH2:26][CH2:25][O:24][CH3:23])([CH2:2][CH2:3]1)[CH2:8][CH2:7]2

Participants

4

Reactant 2

HCID 809722-Bromoethyl methyl etherHCID 239923851-Azabicyclo[2.2.2]oct-4-yl(diphenyl)methanol

Product 1

HCID 11633398HCID 11633398, compoundYield 42.8%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Following the general procedure outlined in Example 4, 1-azabicyclo[2.2.2]oct-4-yl(diphenyl)methanol (0.0597 g, 0.203 mmol) and 2-bromoethyl methyl ether (0.030 mL, 0.319 mmol) in 2 CH3CN/3 CHCl3 (4.0 mL) were reacted to give the desired product (0.0372 g, 42.8%). EI-MS m/z 352(M+) Rt (1.69 min).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-8c66fb74f1244c4a9004d316c6e63c7f
Source dataset
uspto-grants-2009_03
Patent number
US07498440B2

Reaction notes

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