反应详情

温度

100 °C

A mixture of 4.2 g (0.0142 mol) of 2-amino-3-[[[1-(phenylmethyl)-4-piperidinyl]amino]methyl]-pyridine, 2.4 g (0.0148 mol) of N,N′-carbonyldiimidazole and 50 ml of dimethylformamide was heated to 100° C. for 30 minutes. The still warm mixture was stirred into 300 ml of ice water, the precipitate formed was suction filtered and recrystallised from acetonitrile. After drying in vacuo 4.5 g (98.3% of theory) of colourless crystals of melting point 187° C. were obtained.

1. customthe precipitate formed
2. filtrationfiltered
3. customrecrystallised from acetonitrile
4. customAfter drying in vacuo 4.5 g (98.3% of theory) of colourless crystals of melting point 187° C.
5. customwere obtained