Trifluoroacetic acid → HCID 86587637, compound

HRID 1782698Notes

Reaction equation

HRID 1782698 reaction equation
CC(C)(OC([N:7]1[CH2:12][CH2:11][CH:10]([N:13]2[CH2:18][C:17]3=[CH:19][S:20][CH:21]=[C:16]3[NH:15][C:14]2=[O:22])[CH2:9][CH2:8]1)=O)C.[F:24][C:25]([F:30])([F:29])[C:26]([OH:28])=[O:27]>>[NH:7]1[CH2:8][CH2:9][CH:10]([N:13]2[CH2:18][C:17]3=[CH:19][S:20][CH:21]=[C:16]3[NH:15][C:14]2=[O:22])[CH2:11][CH2:12]1.[F:24][C:25]([F:30])([F:29])[C:26]([O-:28])=[O:27]

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 18321456HCID 18321456, compound

Product 1

HCID 86587637HCID 86587637, compound

Procedure

A mixture of 10.0 g (0.0296 mol) of 3,4-dihydro-3-[1-(1,1-dimethylethoxycarbonyl)-4-piperidinyl]-1H-thieno[3,4-d]pyrimidin-2-one and 50 ml of trifluoroacetic acid was stirred at room temperature for 30 minutes. The residue remaining after removal of the excess trifluoroacetic acid was triturated with diethylether and suction filtered. 5.8 g (55.8% of theory) of colourless crystals were obtained, which were used without further purification.

Workup

  1. customafter removal of the excess trifluoroacetic acid
  2. customwas triturated with diethylether and suction
  3. filtrationfiltered
  4. custom5.8 g (55.8% of theory) of colourless crystals were obtained
  5. customwhich were used without further purification

Sources & evidence

ORD record
ord-e7a875b97ebe4b8d8c79a2571fbe561e
Source dataset
uspto-grants-2009_03
Patent number
US07498325B2

Reaction notes

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