Hydrochloric Acid → HCID 18321620, compound

HRID 1782727Notes

Reaction equation

HRID 1782727 reaction equation
CC(C)(OC([NH:7][CH:8]([C:16]([N:18]1[CH2:23][CH2:22][N:21]([C:24]2[CH:29]=[CH:28][N:27]=[CH:26][CH:25]=2)[CH2:20][CH2:19]1)=[O:17])[CH2:9][C:10]1[CH:15]=[CH:14][N:13]=[CH:12][CH:11]=1)=O)C.[ClH:31]>CO>[ClH:31].[N:27]1[CH:28]=[CH:29][C:24]([N:21]2[CH2:20][CH2:19][N:18]([C:16](=[O:17])[CH:8]([CH2:9][C:10]3[CH:15]=[CH:14][N:13]=[CH:12][CH:11]=3)[NH2:7])[CH2:23][CH2:22]2)=[CH:25][CH:26]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 18321091HCID 18321091, compound

Product 1

HCID 18321620HCID 18321620, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
40 °C

Procedure

16.4 g (0.04 mol) of 1-[N-[(1,1-dimethylethoxy)carbonyl]-3-(4-pyridinyl)-D,L-alanyl]-4-(4-pyridinyl)-piperazine, dissolved in 100 ml of methanol, were mixed with 20 ml of ethereal hydrochloric acid and the reaction mixture was heated to 40° C. The desired compound crystallised out of the reaction mixture.

Workup

  1. customThe desired compound crystallised out of the reaction mixture

Sources & evidence

ORD record
ord-b3c063f2fb514a9ebd1c8ae19f5bd66a
Source dataset
uspto-grants-2009_03
Patent number
US07498325B2

Reaction notes

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