Carbon tetrabromide → HCID 57589154, compound

HRID 1782764Notes

Reaction equation

[C:1]1([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH:6]=[CH:5][C:4]([CH2:7][O:8][C:9]2[CH:18]=[CH:17][C:12]([O:13][CH2:14][CH2:15]O)=[CH:11][CH:10]=2)=[CH:3][CH:2]=1.[Br:25]C(Br)(Br)Br.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>ClCCl>[Br:25][CH2:15][CH2:14][O:13][C:12]1[CH:17]=[CH:18][C:9]([O:8][CH2:7][C:4]2[CH:5]=[CH:6][C:1]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)=[CH:2][CH:3]=2)=[CH:10][CH:11]=1

Participants

Conditions

Temperature: 0 °C

Procedure

800 mg of 2-[4-(biphenyl-4-ylmethoxy)phenoxy]ethanol are introduced into 25 ml of dichloromethane under argon, 1.16 g of tetrabromomethane are added, and the mixture is stirred at room temperture for 10 minutes. The mixture is cooled to 0° C. and, after addition of 1.83 g of triphenylphosphine, stirred at 0° C. for one hour and at room temperature for 2 hours. It is concentrated, and the residue is taken up in a little dichloromethane and filtered through silica gel. 480 mg of product are obtained.

Workup

stirringstirred at 0° C. for one hour and at room temperature for 2 hours
concentrationIt is concentrated
filtrationfiltered through silica gel

Sources & evidence

ORD record: ord-a1467a0cad4b4895b545d78df6710d60
Source dataset: uspto-grants-2009_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07498460B2

Reaction notes

Loading…