ethyl (1R,2S)-2-aminocyclohexane-1-carboxylate hydrochloride → Ethyl 4-{3-[4-(1,1'-biphenyl-4-ylmethoxy)phenyl]propoxy}-3-({cis-[2-(ethoxy-carbonyl)cyclohexyl]amino}carbonyl)benzoate

HRID 1782772Notes

Reaction equation

HRID 1782772 reaction equation
[C:1]1([C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)[CH:6]=[CH:5][C:4]([CH2:7][O:8][C:9]2[CH:14]=[CH:13][C:12]([CH2:15][CH2:16][CH2:17][O:18][C:19]3[CH:27]=[CH:26][C:25]([C:28]([O:30][CH2:31][CH3:32])=[O:29])=[CH:24][C:20]=3[C:21](O)=[O:22])=[CH:11][CH:10]=2)=[CH:3][CH:2]=1.Cl.[NH2:40][C@H:41]1[CH2:46][CH2:45][CH2:44][CH2:43][C@H:42]1[C:47]([O:49][CH2:50][CH3:51])=[O:48]>>[C:1]1([C:33]2[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=2)[CH:2]=[CH:3][C:4]([CH2:7][O:8][C:9]2[CH:10]=[CH:11][C:12]([CH2:15][CH2:16][CH2:17][O:18][C:19]3[CH:27]=[CH:26][C:25]([C:28]([O:30][CH2:31][CH3:32])=[O:29])=[CH:24][C:20]=3[C:21]([NH:40][C@@H:41]3[CH2:46][CH2:45][CH2:44][CH2:43][C@@H:42]3[C:47]([O:49][CH2:50][CH3:51])=[O:48])=[O:22])=[CH:13][CH:14]=2)=[CH:5][CH:6]=1

Participants

3

Reactant 2

HCID 2724641ethyl (1R,2S)-2-aminocyclohexane-1-carboxylate hydrochlorideHCID 57589042HCID 57589042, compound

Product 1

HCID 57589228Ethyl 4-{3-[4-(1,1'-biphenyl-4-ylmethoxy)phenyl]propoxy}-3-({cis-[2-(ethoxy-carbonyl)cyclohexyl]amino}carbonyl)benzoate

Procedure

The compound is prepared in analogy to the process described in Example 6 from 2-{3-[4-(1,1′-biphenyl-4-ylmethoxy)phenyl]propoxy}-5-(ethoxycarbonyl)benzoic acid and ethyl cis-2-amino-1-cyclohexanecarboxylate hydrochloride.

Workup

  1. customThe compound is prepared in analogy to the process

Sources & evidence

ORD record
ord-969d106c55664a6ea8e261b2cbb9ca78
Source dataset
uspto-grants-2009_03
Patent number
US07498460B2

Reaction notes

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