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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1782772Generated: October 30, 2026

ethyl (1R,2S)-2-aminocyclohexane-1-carboxylate hydrochloride → Ethyl 4-{3-[4-(1,1'-biphenyl-4-ylmethoxy)phenyl]propoxy}-3-({cis-[2-(ethoxy-carbonyl)cyclohexyl]amino}carbonyl)benzoate

https://huagongshe.com/reaction/1782772

Reaction equation

Participants

RoleNameHCIDCharge
Reactantethyl (1R,2S)-2-aminocyclohexane-1-carboxylate hydrochlorideHCID 2724641—
ReactantHCID 57589042HCID 57589042—
ProductEthyl 4-{3-[4-(1,1'-biphenyl-4-ylmethoxy)phenyl]propoxy}-3-({cis-[2-(ethoxy-carbonyl)cyclohexyl]amino}carbonyl)benzoateHCID 57589228—

Reaction Steps

The compound is prepared in analogy to the process described in Example 6 from 2-{3-[4-(1,1′-biphenyl-4-ylmethoxy)phenyl]propoxy}-5-(ethoxycarbonyl)benzoic acid and ethyl cis-2-amino-1-cyclohexanecarboxylate hydrochloride.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07498460B2
Source datasetuspto-grants-2009_03
ORD IDord-969d106c55664a6ea8e261b2cbb9ca78
Source noteuspto-grants-2009_03