HRID1782792

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COC(=O)c1ccc(O)c(C(=O)NC2CCCC(C(=O)OC)C2)c1

HCID57589182

未命名化合物

HCID69081390

未命名化合物

PRODUCTS

生成物

结构：COC(=O)c1ccc(OCCCc2ccc(CCc3ccc(-c4ccccc4)cc3)cc2)c(C(=O)NC2CCCC(C(=O)OC)C2)c1

HCID57589234

未命名化合物

PROCEDURE

实验过程

Preparation takes place in analogy to Example 22 from the (+)-B-enantiomer of methyl 4-hydroxy-3-({[3-(methoxycarbonyl)cyclohexyl]amino}carbonyl)benzoate (see Example IX, method 2) and 4-{2-[4-(3-iodopropyl)phenyl]ethyl}biphenyl.

WORKUP

后处理

customPreparation

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-03c1f59eee2746c194b6039abe4c9a88
来源数据集: uspto-grants-2009_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07498460B2
来源说明: uspto-grants-2009_03

反应 SMILES

[OH:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][C:3]=1[C:12]([NH:14][CH:15]1[CH2:20][CH2:19][CH2:18][CH:17]([C:21]([O:23][CH3:24])=[O:22])[CH2:16]1)=[O:13].I[CH2:26][CH2:27][CH2:28][C:29]1[CH:34]=[CH:33][C:32]([CH2:35][CH2:36][C:37]2[CH:42]=[CH:41][C:40]([C:43]3[CH:48]=[CH:47][CH:46]=[CH:45][CH:44]=3)=[CH:39][CH:38]=2)=[CH:31][CH:30]=1>>[C:40]1([C:43]2[CH:44]=[CH:45][CH:46]=[CH:47][CH:48]=2)[CH:39]=[CH:38][C:37]([CH2:36][CH2:35][C:32]2[CH:33]=[CH:34][C:29]([CH2:28][CH2:27][CH2:26][O:1][C:2]3[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][C:3]=3[C:12]([NH:14][CH:15]3[CH2:20][CH2:19][CH2:18][CH:17]([C:21]([O:23][CH3:24])=[O:22])[CH2:16]3)=[O:13])=[CH:30][CH:31]=2)=[CH:42][CH:41]=1