HRID1783205

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID18066

1-Aminotetralin

C10H13N

结构：CC(C)(C)OC(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H]1CO1

HCID9922319

tert-Butyl {(1S)-2-(3,5-difluorophenyl)-1-[(2S)-oxiran-2-yl]ethyl}carbamate

C15H19F2NO3

HCID22593642

未命名化合物

PRODUCTS

生成物

结构：CCCN(CCC)C(=O)c1cc(C)cc(C(=O)N[C@@H](Cc2cc(F)cc(F)c2)[C@H](O)CN[C@@H]2CCCc3ccccc32)c1

HCID69417358

未命名化合物

PROCEDURE

实验过程

Following the general procedure of EXAMPLEs 4, 5 and 6 and making non-critical variations but using tert-butyl (1S)-2-(3,5-difluorophenyl)-1-[(2S)-oxiranyl]ethylcarbamate (V, EXAMPLE 3), 1,2,3,4-tetrahydro-1-naphthalenylamine (VI) and “5-Me-PHTH” (IX), the title compound is obtained, MH+=588.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-533c9b618492460ea88ff79eaf41b40f
来源数据集: uspto-grants-2009_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07498436B2
来源说明: uspto-grants-2009_03

反应 SMILES

[F:1][C:2]1[CH:3]=[C:4]([CH2:9][C@H:10]([NH:14][C:15](=[O:21])OC(C)(C)C)[C@H:11]2[CH2:13][O:12]2)[CH:5]=[C:6]([F:8])[CH:7]=1.[CH:22]1([NH2:32])[C:31]2[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=2)[CH2:25][CH2:24][CH2:23]1.[CH2:33]([N:36]([CH2:50][CH2:51][CH3:52])[C:37]([C:39]1[CH:40]=[C:41]([CH:45]=[C:46]([CH2:48]C)[CH:47]=1)C(O)=O)=[O:38])[CH2:34][CH3:35]>>[F:8][C:6]1[CH:5]=[C:4]([CH:3]=[C:2]([F:1])[CH:7]=1)[CH2:9][C@H:10]([NH:14][C:15](=[O:21])[C:41]1[CH:45]=[C:46]([CH3:48])[CH:47]=[C:39]([C:37]([N:36]([CH2:33][CH2:34][CH3:35])[CH2:50][CH2:51][CH3:52])=[O:38])[CH:40]=1)[C@H:11]([OH:12])[CH2:13][NH:32][C@H:22]1[C:31]2[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=2)[CH2:25][CH2:24][CH2:23]1