Tetrahydrofuran → 2,2,2-Trifluoro-1-(9-((4-(2-hydroxyethyl)thiophen-2-yl)methyl)-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)ethanone

HRID 178321Notes

Reaction equation

HRID 178321 reaction equation
[C:19]([Si:20]([CH3:21])([CH3:22])[O:24][CH2:25][CH2:26][c:27]1[cH:28][c:29]([CH2:32][N:33]2[CH2:34][CH2:35][C:36]3([CH2:37][N:38]([C:42]([C:43]([F:44])([F:45])[F:46])=[O:47])[CH2:39][CH2:40][O:41]3)[CH2:48][CH2:49]2)[s:30][cH:31]1)([CH3:23])([CH3:50])[CH3:51].[CH2:2]([N+:3]([CH2:4][CH2:5][CH2:6][CH3:7])([CH2:8][CH2:9][CH2:10][CH3:11])[CH2:12][CH2:13][CH2:14][CH3:15])[CH2:16][CH2:17][CH3:18].[CH2:52]1[O:53][CH2:54][CH2:55][CH2:56]1.[F-:1]>>[OH:24][CH2:25][CH2:26][c:27]1[cH:28][c:29]([CH2:32][N:33]2[CH2:34][CH2:35][C:36]3([CH2:37][N:38]([C:42]([C:43]([F:44])([F:45])[F:46])=[O:47])[CH2:39][CH2:40][O:41]3)[CH2:48][CH2:49]2)[s:30][cH:31]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 16028TetrabutylammoniumHCID 28179Fluoride IonHCID 579892241-(9-((4-(2-(tert-Butyldimethylsilyloxy)ethyl)thiophen-2-yl)methyl)-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)-2,2,2-trifluoroethanone

Product 1

HCID 579890502,2,2-Trifluoro-1-(9-((4-(2-hydroxyethyl)thiophen-2-yl)methyl)-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)ethanone

Sources & evidence

ORD record
ord-edf8f1fd81644a58a721dd787511714d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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