反应详情

6-Methyl-1-indanone (40.4 g) and isoamyl nitrite (40.6 mL) were dissolved in ethanol (300 mL), and 4N hydrogen chloride-dioxane (10 mL) was added dropwise under ice-cooling. After the completion of the reaction, the precipitated crystals were collected by filtration and washed with ether to give 6-methyl-2-hydroxyimino-1-indanone (37 g).

1. temperaturecooling
2. customAfter the completion of the reaction
3. filtrationthe precipitated crystals were collected by filtration
4. washwashed with ether