HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 3-amino-7-methyl-2H-isoquinolin-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Cyanomethyl-5-methylbenzamide | HCID 23084702 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-amino-7-methyl-2H-isoquinolin-1-one | HCID 23084708 | 88.1% |
Reaction Steps
2-Cyanomethyl-5-methylbenzamide (10.9 g) was suspended in methanol (100 mL), and 10% aqueous potassium carbonate solution (100 mL) was added. The mixture was heated under reflux for 1 hr. The precipitated crystals were collected by filtration to give 3-amino-7-methyl-2H-isoquinolin-1-one (9.6 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07501412B2 |
| Source dataset | uspto-grants-2009_03 |
| ORD ID | ord-620af7f975654029a3f778eca92d95f2 |
| Source note | uspto-grants-2009_03 |