Potassium Carbonate → 3-amino-7-methyl-2H-isoquinolin-1-one

HRID 1783299Notes

Reaction equation

HRID 1783299 reaction equation
[C:1]([CH2:3][C:4]1[CH:12]=[CH:11][C:10]([CH3:13])=[CH:9][C:5]=1[C:6]([NH2:8])=[O:7])#[N:2].C(=O)([O-])[O-].[K+].[K+]>CO>[NH2:2][C:1]1[NH:8][C:6](=[O:7])[C:5]2[C:4]([CH:3]=1)=[CH:12][CH:11]=[C:10]([CH3:13])[CH:9]=2

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 230847022-Cyanomethyl-5-methylbenzamide

Product 1

HCID 230847083-amino-7-methyl-2H-isoquinolin-1-oneYield 88.1%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2-Cyanomethyl-5-methylbenzamide (10.9 g) was suspended in methanol (100 mL), and 10% aqueous potassium carbonate solution (100 mL) was added. The mixture was heated under reflux for 1 hr. The precipitated crystals were collected by filtration to give 3-amino-7-methyl-2H-isoquinolin-1-one (9.6 g).

Workup

  1. temperatureThe mixture was heated
  2. temperatureunder reflux for 1 hr
  3. filtrationThe precipitated crystals were collected by filtration

Sources & evidence

ORD record
ord-620af7f975654029a3f778eca92d95f2
Source dataset
uspto-grants-2009_03
Patent number
US07501412B2

Reaction notes

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