Dichloromethane → HCID 22353453, compound

HRID 1783334Notes

Reaction equation

HRID 1783334 reaction equation
[C:1]([NH:4][CH2:5][CH2:6][NH:7][C:8]1[N:13]=[C:12]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[N:11]=[C:10]([NH:20][C:21](=[O:26])[C:22]([O:24]C)=[O:23])[CH:9]=1)(=[O:3])[CH3:2].C1(N2CCNCC2)C=CC=CC=1.ClCCl>CS(C)=O>[C:1]([NH:4][CH2:5][CH2:6][NH:7][C:8]1[N:13]=[C:12]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[N:11]=[C:10]([NH:20][C:21](=[O:26])[C:22]([OH:24])=[O:23])[CH:9]=1)(=[O:3])[CH3:2]

Participants

5

Reactant 3

HCID 6344DichloromethaneHCID 70961-PhenylpiperazineHCID 20811457HCID 20811457, compound

Product 1

HCID 22353453HCID 22353453, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

To a well of a 96 well microtitre plate were added methyl [(6-{[2-(acetylamino)ethyl]amino}-2-phenylpyrimidin-4-yl)amino](oxo)acetate (30 μl of a 0.3M solution in anhydrous DMSO) and 4-phenylpiperazine (30 μl of a 1.5M solution). This solution was left to shake on a plate shaker for 16 hrs. After this time 800 μl of dichloromethane were added, then 100 mg of PS-NCO. The plate was sealed, then mixed for 48 hrs. The slurry was filtered and the solvents removed in vacuo, to furnish the title compound.

Workup

  1. waitThis solution was left
  2. customThe plate was sealed
  3. additionmixed for 48 hrs
  4. filtrationThe slurry was filtered
  5. customthe solvents removed in vacuo

Sources & evidence

ORD record
ord-b37195723c8b43a3b72b2487af64c3c4
Source dataset
uspto-grants-2009_03
Patent number
US07501407B2

Reaction notes

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