Dimethylamine → HCID 24759022, compound

HRID 1783384Notes

Reaction equation

HRID 1783384 reaction equation
[CH3:1][NH:2][CH3:3].[F:4][C:5]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:6]=1[C:7]([C:14](=[O:33])[C:15]([N:17]1[CH2:22][CH2:21][N:20]([C:23]3[C:24](=[O:32])[C:25](=[O:31])[C:26]=3OC(C)C)[CH2:19][CH2:18]1)=[O:16])=[CH:8][NH:9]2>C(O)C>[F:4][C:5]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:6]=1[C:7]([C:14](=[O:33])[C:15]([N:17]1[CH2:18][CH2:19][N:20]([C:23]3[C:24](=[O:32])[C:25](=[O:31])[C:26]=3[N:2]([CH3:3])[CH3:1])[CH2:21][CH2:22]1)=[O:16])=[CH:8][NH:9]2

Participants

4

Reactant 2

HCID 674DimethylamineHCID 24759018HCID 24759018, compound

Product 1

HCID 24759022HCID 24759022, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a saturated solution of dimethylamine in ethanol (2 mL), cooled at 5° C. under Ar, was added 3-[4-[2-(4-fluoro-1H-indol-3-yl)-2-oxoacetyl]piperazin1-yl]-4-isopropoxy-cyclobut-3-ene-1,2-dione (0.020 g, 0.048 mmol) and the mixture was then allowed to stir at room temperature for 2 h. The volatiles were then removed in vacuo to give the essentially pure title compound (0.019 g, 99%) as a white solid:

Workup

  1. customThe volatiles were then removed in vacuo

Sources & evidence

ORD record
ord-24fc9d4575e24c72add2703e98910e41
Source dataset
uspto-grants-2009_03
Patent number
US07501419B2

Reaction notes

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