反应详情

4-Chloro-N-((R)-5,5-difluoro-2-oxo-azepan-3-yl)-N-piperidin-4-ylmethyl-benzenesulfonamide (0.04 g, 0.09 mmol) and triethylamine (19 mg, 0.18 mmol) were dissolved in dichloromethane (1.5 ml). Then benzoyl chloride (0.018 g, 0.13 mmol) was added and the mixture was stirred overnight at room temperature. The reaction mixture was partitioned between aqueous sodium bicarbonate solution and ethyl acetate. The organic layer was dried (MgSO4) and concentrated under reduced pressure. The residue was purified over silica gel (heptane/ethyl acetate 1:1) to yield 29 mg (58%) of the title compound;

1. customThe reaction mixture was partitioned between aqueous sodium bicarbonate solution and ethyl acetate
2. dry with materialThe organic layer was dried (MgSO4)
3. concentrationconcentrated under reduced pressure
4. customThe residue was purified over silica gel (heptane/ethyl acetate 1:1)